Although the body can make it, many people find supplementing SAMe helpful. SAMe helps neurotransmitters - the nervous system' s chemical messengers - deliver their messages to the receptor sites. It can also aid a good night' s sleep and stimulate dreaming because it is one of the precursors of the sleep hormone melatonin. SAMe has been proven to be a good anti-depressant, and can generally enhance feelings of wellbeing and connection. It should be taken on an empty stomach, preferably one hour away from food. Start with a dosage of 200mg twice daily, but that can be increased to a maximum of 400mg four times daily, if needed. SAMe should also be taken with its cofactors, vitamins B6, B12 and folic acid.

You may find SAMe too expensive, however; and it is also relatively unstable as a supplement. A good alternative is to supplement TMG (trimethylglycine), the chemical from which the body makes SAMe, as it' s cheaper and much more stable. You need three times as much TMG as SAMe, so start with l,200mg.